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What is AOD-9604?

AOD stands for anti-obesity drug. It is comprised of the last 16 amino acids of the larger growth hormone molecule. This is an excellent peptide for fat loss. AOD is also popular in the space of regenerative medicine. There have been studies where it has been beneficial in the treatment of osteoarthritis. This peptide acts in amplifying proteoglycan and collagen production in chondrocytes, differentiation of adipose stem cells into bone and differentiation of myoblasts into C2C12 cells. All of which is essential for bone, cartilage, and muscle repair. Studies have shown AOD has been more beneficial compared to BMAC and PRP for regenerative medicine in osteoarthritis. 

Clinical Trial:

Ann Clin Lab Sci. 2015 Summer;45(4):426-32. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Kwon DR1, Park GY2.

Background: To investigate the effects of AOD9604 intra-articular injections with or without hyaluronic acid (HA) in a collagenase-induced knee osteoarthritis (OA) rabbit model.

Design: Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint. Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the rst intra-articular collagenase injection. The degree of cartilage degeneration was assessed using morphological and histopathological findings, and the degree of lameness was observed at 8 weeks after the first collagenase injection.

Results: Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4, and the scores were significantly lower in Group 4 than in Groups 2 and 3. The lameness period in Group 4 was significantly shorter than those in Groups 1, 2, and 3. The lameness period in Group 1 was significantly longer than those in Groups 2 and 3.

Conclusion: AOD9604 enhanced cartilage regeneration, and combined AOD9604 and HA injections were more effective than HA or AOD9604 alone in the collagenase-induced knee OA rabbit model.

A full copy of all trials are available from Tailor Made Compounding Pharmacy